Bacteriocins are antimicrobial substances produced by bacteria which inhibit the growth of similar or closely related bacterial strains in their ecological niches for self-preservation and competitive advantage. As bacteriocins are colorless, odorless, and tasteless and get easily degraded by proteolytic enzymes due to their proteinaceous nature, this improves their potential usability as "designer drugs" to target specific bacterial pathogens. Bacteriocins show great promise and offer applications as anti-bacterial, anti-viral, anti-cancer, antibiofilm agents and may be considered as an alternative to antimicrobial use. The strong specific activity of bacteriocins against clinical pathogens, even against multidrug resistance strains, offers a possible solution to the growing problem of AMR.