Insecticide resistance is the mechanism of detoxification of synthetic chemical insecticide through various methods that involve several detoxifying enzymes as well as metabolic pathways, which are directly controlled by the over-expression of some resistant genes expressed at specific loci at the insect chromosomes. The resistance can be broken by extraction or modification of that gene involved, which in turn changes the expression pattern of several xenobiotic compounds inside the insect body. This review article comprises several resistant genes involved in insecticide resistance in rice brown planthopper (BPH), Nilaparvata lugens (Stal), along with molecular methods involving genetic alteration of resistant genes involved in resistance.