Whole genome sequencing (WGS) has revolutionized the landscape of genomic research and clinical diagnostics, offering unprecedented insights into genetic variation, disease susceptibility, and personalized medicine. As the demand for comprehensive genomic analysis continues to surge, the development of high throughput sequencing (HTS) platforms has been instrumental in enhancing the efficiency, accuracy, and scalability of WGS workflows. This article provides an overview of the recent advancements in HTS platforms tailored for WGS applications. We discuss the evolution of sequencing technologies, highlighting key milestones from Sanger sequencing to next-generation sequencing (NGS) and beyond. Furthermore, we examine the integration of HTS platforms with automated sample preparation systems and bioinformatics pipelines to streamline WGS workflows and reduce turnaround times. We also discuss the challenges and opportunities associated with data analysis, interpretation, and storage in the era of big genomic data.