This article delves into the intricate web of mosquito-borne diseases (MBDs), encompassing prevalent threats such as malaria, dengue, filariasis, chikungunya, Japanese encephalitis, and Zika. With nearly 500 million individuals affected by malaria and 100 million by lymphatic filariasis annually, and approximately 25,000 deaths attributed to dengue each year, understanding the global incidence of these diseases is paramount. The control of diseasetransmitting vectors poses a significant challenge worldwide, with synthetic pesticides serving as primary tools for larval and adult mosquito control. However, the emergence of resistance impedes their efficacy. This comprehensive analysis sheds light on the current global landscape of MBDs and underscores the need for sustainable solutions in combatting these pervasive threats.