African swine fever (ASF) is one of the most dreaded disease of pigs, can cause mortality of up to 100%. It is included among the highly contagious disease of swine that include among the List A diseases by the Office International des Epizooties (OIE). Following disease outbreaks with high mortality in pigs in states of north-east India, namely Arunachal Pradesh and Assam in early 2020 in which 3710 pigs died of ASF. In Mizoram, 12,568 pigs were reported to have been killed in the year 2021, 11,594 pigs were killed during the second wave of the disease in the year 2022. In 2023, Mizoram experienced the third wave of ASF, resulting in dead of 980 pigs and culling of 590 pigs. There is also report of ASF in Manipur during October 2023. This is due to porous border of NE states of India. There is no vaccine available commercially.