Protease is one of most important enzymes having wide application in industries. It is used for hydrolysis of proteins. Among all enzymes used, proteases represent 60% of the enzyme market. Protease can be produced from plants, animal and microorganisms, but 66% of the proteases are derived from the microbial sources. Microbes are easy to cultivate, so can be used for enzyme production in short span of time. Microorganisms act as an important source of enzymes because of their vast distribution, high reproduction, and potential to be genetically altered for higher productivity.