Potato (Solanum tuberosum L.) is a vital food crop known for its high yield and nutritional value. Biotechnology plays a significant role in potato improvement through tissue culture techniques, such as meristem culture, embryo culture, somatic hybridization, and micro propagation, facilitating the production of disease-free planting material and trait transfer. Genetic engineering allows for the introduction of pest and disease resistance genes, contributing to increased crop productivity and reduced pesticide use. Additionally, molecular marker systems aid in efficient selection of desirable traits. These biotechnological advancements hold great promise for enhancing potato production, disease resistance, and nutritional quality, positively impacting global food security and agricultural sustainability.