Disease outbreaks pose significant threats to global agriculture, leading to substantial yield losses and economic damages. Traditional disease management approaches, such as chemical pesticides and fungicides, have proven effective but come with various environmental and health concerns. Biological disease management, on the other hand, offers an eco-friendly and sustainable solution by utilizing natural mechanisms and beneficial organisms to control plant diseases. This comprehensive review explores the various components of biological disease management, including the use of biocontrol agents, induced plant resistance, biological fungicides, and biotechnological tools. The integration of these strategies provides a multifaceted approach to disease management, ensuring crop health, environmental protection, and long-term agricultural sustainability.