In an era defined by escalating global demands for sustenance, energy, and renewable resources, the imperative to reimagine agricultural systems for enhanced productivity, sustainability and resilience is paramount. Modern biotechnological methodologies, including metabolic engineering and synthetic biology, present innovative avenues to fortify crops with superior traits. Metabolic engineering entails the fine-tuning or introduction of genes or gene networks to bolster the production of specific compounds within living organisms. In parallel, synthetic biology orchestrates the creation of novel biological pathways for synthesizing unprecedented compounds. The interplay between these fields is manifest in "synthetic metabolic engineering" (SME), a combined technique that harnesses genetic manipulation and intricate biochemical pathways to design crops with augmented attributes, enriched nutritional profiles, and heightened endurance against environmental adversities.