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Interpretation of Liver Function Tests in Canine and Feline

The liver is unique in that it receives the majority of its blood supply (75%) via the portal venous system, which empties abdominal organs such as the GI tract, spleen, and pancreas. 1,2 This means that illnesses of the pancreas and GI tract can have a secondary effect on the liver. The liver also metabolises and/or excretes a variety of exogenous substances (such as medicines and poisons) that can induce secondary liver damage. The most important enzymes to look for during a liver function test are ALT (alanine transaminase)/SGPT, AST (aspartate transaminase)/SGOT, ALP (alkaline phosphate), ALP (alkaline phosphatase), GGT (gamma-glutamyltransferase), total bilirubin, hypo/hyper proteinemia, albumin-globulin ratio, Triglycerides/cholesterol.