The immense threat posed to the environment due to anthropogenic activities has led to thinking about novel strategies for management of insect pests. Omics is a general term used to describe several rapidly growing fields of science that study large sets of biological molecules. It incorporates the "omics" methods allowing identification of genes (genomics) along with their RNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics) expression levels. Modern era omic-approaches viz., genomics, proteomics, transcriptomics, peptidomics, QTLomics, metabolomics and fluxomics provide insights into the molecular mechanisms of insect resistance to pesticides, changes in cell physiology, plant defense responses against insect attack, cellular strategies to fight against pathogens, role of gene expression in the divergence of insect biotypes, colour forms and the tolerance of plants to insects for better pest management.